In the precision medicine landscape, the value of a biospecimen is defined by the data it carries. Purchasing a tissue block without verified protein expression data adds weeks of validation time and significant cost to your research.
To streamline your drug discovery and diagnostic development, you need a partner that provides IHC-verified FFPE tissue blocks. This integrated approach ensures that every sample you procure is “research-ready,” allowing you to move directly to your primary assays with confidence in the specimen’s biological profile.
The Advantage of Pre-Verified IHC Marker Testing
When you buy FFPE samples with IHC marker testing included, you eliminate the “guesswork” of procurement. This is particularly critical for:
- Targeted Therapy Validation: Instantly source cohorts with high (3+), moderate (2+), or low (1+) expression levels for markers like HER2, PD-L1, or EGFR.
- Immune Profiling: Access samples pre-characterized for tumor-infiltrating lymphocytes (TILs) using CD3, CD4, CD8, and CD68 markers.
- Subtype Stratification: Differentiate complex diseases like breast cancer (Luminal A vs. B vs. Triple Negative) or lung cancer (Adenocarcinoma vs. Squamous Cell) using verified panels of ER, PR, p63, and TTF-1.
Comprehensive IHC Panels Available
We offer a wide range of standard and custom IHC testing included with our FFPE blocks, spanning across multiple oncology indications:
- Immuno-Oncology (I-O) Panels
- PD-L1 (22C3, SP263, SP142): Crucial for pembrolizumab and nivolumab eligibility studies.
- Pan-CK & Vimentin: To study epithelial-mesenchymal transition (EMT) and tumor boundaries.
- Mismatch Repair (MMR): Comprehensive testing for MLH1, MSH2, MSH6, and PMS2 to identify dMMR/MSI-H status.
- Solid Tumor Characterization
- Breast Cancer: ER, PR, HER2 (with FISH follow-up if 2+), and Ki-67 for proliferation index.
- Gastrointestinal (GI): GPC3 for Liver Cancer, CEA, and CA19-9 for Pancreatic and Biliary cancers.
- Prostate: PSA, PSMA, and AR (Androgen Receptor) status.
- Rare and Specialized Markers
- Neuroendocrine Markers: Chromogranin A, Synaptophysin, and CD56.
- Sarcoma Markers: Desmin, S100, and MDM2.
- Brain Tumors: GFAP and IDH1-R132H mutation-specific IHC.
Technical Excellence: Our IHC Process
Our IHC testing is performed in CLIA-certified or ISO-accredited environments, ensuring that the results you receive are of clinical-grade quality.
- Freshly Cut Sections: To prevent epitope loss due to “slide aging,” we perform IHC on freshly cut sections from the original FFPE block.
- Pathologist Scoring: Every slide is reviewed and scored by a board-certified pathologist. We provide the Total Proportion Score (TPS), Combined Positive Score (CPS), or H-score depending on your study requirements.
- High-Resolution Imaging: Along with the physical block, you receive high-resolution digital scans of the IHC-stained slides, allowing you to pre-visualize the expression patterns before the tissue arrives at your lab.
Deep Clinical Annotation
Buying a pre-tested sample provides the molecular context, but our clinical history data provides the “why.” Every IHC-verified block is accompanied by:
- Treatment History: Documentation of whether the expression was measured before or after systemic therapy.
- Anatomical Site: Verification if the sample is from the primary tumor or a specific metastatic site (e.g., liver vs. lung metastasis).
- TNM Staging: Full pathological staging according to the latest AJCC criteria.
Global Logistics and Quality Assurance
We understand the complexities of moving biological material across borders. Our logistics team handles:
- Material Transfer Agreements (MTAs): Streamlined legal processes for rapid procurement.
- Climate-Controlled Shipping: Ensuring the paraffin integrity of the blocks is maintained from our facility to your lab.
- Certificate of Analysis (CoA): Every sample comes with a CoA detailing the IHC staining protocol, antibody clones used, and the pathologist’s final score.
Partner with the Experts in Molecular Tissue Procurement
In the race to bring new therapies to market, don’t let procurement be your bottleneck. By choosing FFPE samples with included IHC marker testing, you gain a strategic advantage in speed, accuracy, and data depth.
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Advance your research with the world’s most reliable, pre-characterized tissue repository. Contact our procurement team today for an inventory report tailored to your specific IHC marker requirements.
